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The side effects listed below are not experienced by everyone who takes this medication. If you are concerned about side effects, discuss the risks and benefits of this medication with your doctor.

The following side effects have been reported by at least 1% of people taking this medication. Many of these side effects can be managed, and some may go away on their own over time.

Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.

  • difficulty in wearing contact lenses (may continue after treatment is stopped)
  • dry eyes (may continue after treatment is stopped)
  • dry or itchy skin
  • dry mouth or nose
  • headache (mild)
  • hoarseness
  • increased sensitivity of skin to sunlight
  • nosebleeds
  • pain or tenderness of eyes
  • peeling of skin on palms of hands or soles of feet
  • stomach upset
  • thinning of hair (may continue after treatment is stopped)
  • unusual tiredness

Although most of the side effects listed below don’t happen very often, they could lead to serious problems if you do not seek medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

  • attempts at suicide or thoughts of suicide (usually stops after medication is stopped)
  • back pain
  • bleeding or inflammation of gums
  • blurred vision or other changes in vision
  • bone or joint pain
  • burning, redness, itching, or other signs of eye inflammation
  • changes in behaviour
  • decreased hearing
  • decreased vision after sunset or before sunrise (sudden or may continue after medication is stopped)
  • difficulty in moving
  • headache (severe or continuing)
  • nausea and vomiting
  • pain, tenderness, or stiffness in muscles (long-term treatment)
  • ringing in the ears
  • scaling, redness, burning, pain, or other signs of inflammation of lips
  • signs of depression (e.g. poor concentration, changes in weight, changes in sleep, decreased interest in activities, thoughts of suicide)
  • signs of inflammatory bowel disease (e.g. severe abdominal or stomach pain, severe diarrhea, rectal bleeding)
  • signs of liver problems (e.g. nausea, vomiting, diarrhea, loss of appetite, weight loss, yellowing of the skin or whites of the eyes, dark urine, pale stools)
  • skin infection or rash

Stop taking the medication and seek immediate medical attention if any of the following occur:

  • signs of pancreatitis (e.g. abdominal pain on the upper left side, back pain, nausea, fever, chills, rapid heartbeat, swollen abdomen)
  • signs of a serious allergic reaction (e.g. abdominal cramps, difficulty breathing, nausea and vomiting, or swelling of the face and throat)
  • signs of a severe skin reaction such as blistering, peeling, a rash covering a large area of the body, a rash that spreads quickly, or a rash combined with fever or discomfort

Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking this medication.

Are there any other precautions or warnings for this medication?

Before you begin using a medication, be sure to inform your doctor of any medical conditions or allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use this medication.

Behaviour changes and suicidal thoughts: Some people taking this medication have experienced depression, including thoughts of suicide. If you experience any behaviour change or symptoms such as sad mood, hopelessness, feelings of guilt, loss of pleasure or interest in activities, changes in sleep pattern, irritability, or restlessness while taking this medication, contact your doctor immediately.

Family members or caregivers of people who are taking this medication should contact the person’s doctor immediately if they notice unusual behaviour changes.

Blood donation: You should not give blood during treatment with isotretinoin and for one month after stopping treatment in case the blood is given to a pregnant woman.